Secrets Of The Heart
Thanks to comprehensive research into inherited heart conditions, doctors can now recognise the warning signs earlier than ever before. By looking for common clues, like a pale ring around the iris, scientists were even able to deduce that Mona Lisa may have had the inherited condition familial hypercholesterolaemia.
Secrets of the Heart
Researchers are working hard with cardiac surgeons to find the most effective ways of attaching bacteria-based polymer patches onto areas of damaged heart muscle. Once there, the patch will repair any damage by growing new healthy heart cells.
Stenting (angioplasty) involves the widening of narrowed coronary arteries by inserting a small mesh tube to reduce the symptoms of coronary heart disease (CHD). Our next generation of stents emit carbon monoxide-releasing molecules to lessen the chance of the artery re-closing with scar tissue.
Now, as director of preventive cardiology at Massachusetts General Hospital, assistant professor of medicine at Harvard Medical School, and associate member of the Broad Institute of MIT and Harvard, Natarajan fights cardiovascular disease on several fronts. As a physician-scientist, he both cares for patients in the clinic and works in the lab, identifying and characterizing the root causes of heart disease to promote prevention. Specifically, he analyzes naturally-occurring genetic variation in humans to identify genes that influence cardiovascular diseases and traits. This information can help Natarajan and other researchers predict who might be at risk of developing cardiovascular disease, and whether targeting specific biomarkers with therapeutics might benefit certain patients.
Background: In patients with acute heart failure (AHF), dyspnea relief is the most immediate goal. Renal dysfunction, diuretic resistance, and hyponatremia represent treatment impediments.
The protagonist is Javi, a boy of approximately ten years old. Javi and his older brother Juan spend the week with their aunts Rosa and Maria in the city, where they attend a private Catholic school. On the weekend they take the bus to their home, a farmhouse in a rural village, where they live with their mother Teresa and uncle Ignacio, their father Antonio having died some years before. Over the course of the Easter holiday, the relentlessly inquisitive young Javi will discover some long-hidden truths...it seems the family is hiding several secrets.
Big, Screwed-Up Family: Aunt Rosa is a lonely spinster. Aunt Maria is an alcoholic who also had an affair with a married man; she rekindles the affair and they run away together. The brother's father Antonio didn't die from a gun accident, he killed himself. The reason he killed himself was the fact that his brother Ignacio was having an affair with his wife. And as it turns out, "Uncle" Ignacio is actually Javi's father.
Call-Back: Across the street from the apartment building, there's a park with a stream, and a bridge made of paving stones with no handrails. In the very first scene, Juan makes fun of his little brother for being too scared of the stone bridge and taking the safer handrail-equipped bridge instead. Near the end, when Aunt Maria is walking away on the stone bridge, Javi walks across it to catch her, symbolizing how he is growing up.
Coming of Age Story: A schoolboy learns about sex, learns about the frailties of his parents, and learns who his real father is.
Driven to Suicide: In the back story, Antonio killed himself because he found out that his wife was cheating on him with his brother.
Foreshadowing: Young Javi gets a little sex ed lesson when he takes family dog Perla out for a walk, and Perla the girl dog meets a boy dog who proceeds to mate with her. This foreshadows a later scene in which he hears his mother and uncle having sex in the home.
Hangover Sensitivity: Maria wakes up with a wicked hangover; she blames it on blood pressure.
Lady Drunk: Aunt Maria drinks excessively, often passing out on the bed and waking up with a hangover which she blames on "blood pressure". It's implied that she is broken-hearted after the end of her affair with Ricardo.
The Mistress: A single line from Aunt Rosa about Ricardo's family indicates that Aunt Maria is this. Having restarted the affair, Aunt Maria says she doesn't care anymore, and she and Ricardo run away.
One-Gender School: Javi and Juan go to a Catholic school for boys.
Primal Scene: In addition to the Right Through the Wall scene described below, Javi also peeks in the old, formerly empty house where Ricardo is now staying. He sees Ricardo having sex with Maria on a couch.
Right Through the Wall: Juan, messing with Javi, tells Javi that if he goes and sits in the seat where their father died, he'll hear his father's ghost. So Javi does, and hears the sounds of his mom and uncle having sex in the next room.
School Play: Javi is playing the lead of "Chickpea" in the school play, some sort of fairy tale wherein a boy wanders into the forest and runs afoul of an evil wizard.
Smoking Is Cool: Juan and his friends like to sneak cigarettes to be more grownup.
Title Drop: Teresa tells Javi that people keep their worst secrets in their heart.
Train-Station Goodbye: With a bus, but it's basically the same, as Aunt Maria trots after the bus and tells the boys to be good at their mom's house.
According to the National Heart, Lung and Blood Institute, being overweight can increase your chances of falling victim to an array of serious ailments such as heart disease. A good way to make sure you are at a healthy weight is to keep tabs on your body mass index. To find your current BMI, plug your weight and height into the MyFitnessPal BMI Calculator. The tool helps you to determine whether or not your BMI falls within a normal range and also suggests a target weight range to aim for if your current body mass index falls outside the healthy zone.
Abstract:The adult human heart cannot repair itself after injury and, instead, forms a permanent fibrotic scar that impairs cardiac function and can lead to incurable heart failure. The zebrafish, amongst other organisms, has been extensively studied for its innate capacity to repair its heart after injury. Understanding the signals that govern successful regeneration in models such as the zebrafish will lead to the development of effective therapies that can stimulate endogenous repair in humans. To date, many studies have investigated cardiac regeneration using a reverse genetics candidate gene approach. However, this approach is limited in its ability to unbiasedly identify novel genes and signalling pathways that are essential to successful regeneration. In contrast, drawing comparisons between different models of regeneration enables unbiased screens to be performed, identifying signals that have not previously been linked to regeneration. Here, we will review in detail what has been learnt from the comparative approach, highlighting the techniques used and how these studies have influenced the field. We will also discuss what further comparisons would enhance our knowledge of successful regeneration and scarring. Finally, we focus on the Astyanax mexicanus, an intraspecies comparative fish model that holds great promise for revealing the secrets of the regenerating heart.Keywords: heart; regeneration; scarring; zebrafish; teleost fish; Astyanax mexicanus; comparative approach; interorgan
Low heart-rate training was pioneered by running coach Phil Maffetone, who found that it was a very efficient form of running training that improves the aerobic fitness of athletes without over training. Its benefits have already been shown by world class athletes who improved their performance while using the low heart rate training.
I discovered low heart rate training a few years ago. One of my friends bought a heart rate monitor and I tried it out on one of my daily training runs. I was shocked to find my heart rate was around 180 on even my easy runs. I felt no strain while running but on reflection I realised I would often feel tired during the day and would regularly get colds and flu-like symptoms.
Around this time I discovered Phil Maffetone, a running coach who had trained the famous triathlete Mark Allen (six time winner of the Hawaii Ironman) and was one of the pioneers of low heart rate training. Triathletes often overtrain because of the volume of training they have to do.
Maffetone had discovered that many athletes were very fit but at the same time unhealthy owing to overtraining. So after much research he came up with a form of low heart rate training which improved aerobic function without overtraining.
So I tried to train at this new low heart rate. I had been warned that you need a lot of patience at first and this was indeed the case. I was only able to run for a short distance before my heart rate would jump up to around 180. I needed to be really self-disciplined at this point and I decided not to give up and to plough on regardless.
This continued for a couple of weeks of walk/run and was quite frustrating. But with persistent effort, after about a month, I was able to run more consistently at the low heart rate. My pace was very slow but my heart rate seemed to reset itself at this new lower heart rate after a while. Each month I got faster and after 3 months I was able to run at my normal training pace.
Whereas my heart rate had been around 180 at this training speed it was now 120 for short runs. Gradually each month I was able to run for longer and to keep my new low heart rate. This also meant I didn't feel so tired during the day and didn't get so many colds etc.
Maffetone found that most of his top triathletes were able to gradually increase their speed each month until they could get close to their race speed while still maintaining their low heart rate. 041b061a72